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At Spyre, we are guided by our mission to develop potentially best-in-class therapeutics for people living with IBD. We are a collaborative interdisciplinary team, united in our drive to innovate and dedicated to enhancing patient lives. If you’re passionate about making a tangible difference and thrive in a dynamic environment, we invite you to apply to join our pioneering organization.

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A group of people smiling and posing for a photo outside on a brick street.
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A group of people in front of a large screen discussing the differences between Crohn’s Disease and Ulcerative Colitis.

YOUR FUTURE AWAITS

Apply to join our growing team of scientists and development professionals.

Spyre’s Candidate Privacy Policy explains how your personal information is utilized during the application process.

OUR VALUES DRIVE OUR CULTURE

We are driven by our passion and dedication to improve the lives of those living with IBD.

By holding ourselves to the highest standard of performance, together we challenge what’s possible and embrace diverse perspectives while maintaining a strong culture where courage and resilience are celebrated.

Breakthrough Discoveries

We target impactful improvements in therapeutic efficacy and convenience to meaningfully improve the lives of patients.

Uncompromising Innovation

We work at the highest level of scientific and clinical rigor, designing studies to answer critical questions with urgency.

Courageous Dissent

We bring strong, data-driven opinions and encourage diversity of thought to advance the best ideas.

Ownership Mindset

We hold ourselves to the highest standard of performance, quality, and integrity as we work through challenges and ambiguity.

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GET INSPYRED

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A group of employees holding skateboards from their Skate Like a Girl event.
The women on the Spyre team standing in front of the Nasdaq billboard.
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A group of people smiling and posing on the beach at night.
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“My time at Spyre has been exceptional, thanks to its dynamic and supportive work environment that continually inspires professional growth. The company’s commitment to innovation and teamwork makes every day exciting and fulfilling!“

Alex Delp

Director, CMC Operations

Inclusion, Belonging & Culture

Our team members foster a culture of empowering each other to bring our true selves to Spyre in order to reach new heights in the treatment of our patients. We do this by leveraging the power of diverse perspectives through mutual respect, equitable treatment and upholding an inclusive environment.

OUR BENEFIT OFFERINGS

Spyre offers an opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture of our young company, wear multiple hats, and learn quickly. We are committed to growing you professionally and providing access to resources to further your development.

We offer a comprehensive benefits package for all new employees:

Competitive compensation inclusive of base salary, performance bonus, equity grant opportunities, and retirement benefits.

Coverage inclusive of medical, dental, vision, health and wellness reimbursements.

Flexible PTO and two, one-week company-wide shutdowns each year.

100% remote with frequent all team, in-person meetings to build relationships and problem solve.

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ADVANCE YOUR CAREER WITH SPYRE

Explore Opportunities

As we continue to grow, new positions will be posted. Check back often for updates if you don’t see a suitable match today.

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Open Positions

Applying to Spyre Therapeutics

Please be aware that Spyre Therapeutics will never initiate contact with applicants via text message or through messaging apps, freelance sites, or social media platforms (Facebook, Telegram, Instagram, Skype, WhatsApp, etc.).

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.