At Spyre, we are driven by our mission to develop potentially best-in-class therapeutics for people living with IBD. We are a collaborative interdisciplinary team of innovators seeking motivated individuals who are looking to make a positive impact and join an exciting new organization.

As we continue to grow, new positions will be posted. Check back regularly if you don’t see anything that matches your current interests.

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Join our growing team of scientists and development professionals

Spyre’s Candidate Privacy Policy explains how your personal information is utilized during the application process.


We are driven by our passion and dedication to improve the lives of those living with IBD.

By holding ourselves to the highest standard of performance, together we challenge what’s possible and embrace diverse perspectives while maintaining a strong culture where courage and resilience are celebrated.

Breakthrough Discoveries

We target impactful improvements in therapeutic efficacy and convenience to meaningfully improve the lives of patients.

Uncompromising Innovation

We work at the highest level of scientific and clinical rigor, designing studies to answer critical questions with urgency.

Courageous Dissent

We bring strong, data-driven opinions and encourage diversity of thought to advance the best ideas.

Ownership Mindset

We hold ourselves to the highest standard of performance, quality, and integrity as we work through challenges and ambiguity.

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Spyre offers an opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture of our young company, wear multiple hats, and learn quickly. We are committed to growing you professionally and providing access to resources to further your development.

We offer a comprehensive benefits package for all new employees:

Flexible PTO and two, one-week company-wide shutdowns each year.

100% remote with frequent all team, in-person meetings to build relationships and problem solve.

Competitive compensation inclusive of base salary, performance bonus, equity grant opportunities, and retirement benefits.

Coverage inclusive of medical, dental, vision, health and wellness reimbursements.


Please be aware that Spyre Therapeutics will never initiate contact with applicants via text message or through messaging apps, freelance sites, or social media platforms (Facebook, Telegram, Instagram, Skype, WhatsApp, etc.).

If you have submitted an application but have not heard back, you can reach us directly via email at

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.