At Spyre, we are driven by our mission to develop potentially best-in-class therapeutics for people living with IBD. We are a collaborative interdisciplinary team of innovators seeking motivated individuals who are looking to make a positive impact and join an exciting new organization.

As we continue to grow, new positions will be posted. Check back regularly if you don’t see anything that matches your current interests.


Join our growing team of scientists and development professionals

Spyre’s Candidate Privacy Policy explains how your personal information is utilized during the application process.

White patternWhite pattern


Spyre offers an opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture of our young company, wear multiple hats, and learn quickly. We are committed to growing you professionally and providing access to resources to further your development.

We offer a comprehensive benefits package for all new employees:

Flexible PTO and two, one-week company-wide shutdowns each year.

100% remote with frequent all team, in-person meetings to build relationships and problem solve.

Competitive compensation inclusive of base salary, performance bonus, equity grant opportunities, and retirement benefits.

Coverage inclusive of medical, dental, vision, health and wellness reimbursements.


Please be aware that Spyre Therapeutics will never initiate contact with applicants via text message or through messaging apps, freelance sites, or social media platforms (Facebook, Telegram, Instagram, Skype, WhatsApp, etc.).

If you have submitted an application but have not heard back, you can reach us directly via email at

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.