Seeking to develop better antibodies

Today's monoclonal antibodies (mAbs) were demonstrated to be effective for the treatment of IBD, but the disease is still not adequately addressed in many patients. Spyre's pipeline builds on the validated biology of first-generation antibodies with the goal of developing and bringing to market novel therapies that improve efficacy and convenience for IBD patients.

Together with our partners, we apply expertise in protein engineering across five key properties:

Potency
Specificity
Pharmacokinetics

Half-life extension

Formulatability
Manufacturability
3D rendering of a monoclonal antibody in pink and purple
3D rendering of a monoclonal antibody in pink and purple
3D rendering of a monoclonal antibody in pink and purple
pink pattern

RATIONAL COMBINATIONS

At Spyre, we are advancing rational combinations of therapeutic antibody product candidates. Our pre-clinical and planned clinical studies aim to study the safety and efficacy of the following combinations of our next generation product candidates to target IBD:

  • SPY120 program: combines product candidates SPY001 (α4β7) and SPY002 (TL1A).
  • SPY130 program: combines SPY001 (α4β7) and SPY003 (IL-23).
  • SPY230 program: combines SPY002 (TL1A) and SPY003 (IL-23).

We are pursuing combination studies for our next-generation monoclonal antibodies informed by recent findings from research on combination approaches with third-party products in IBD.*

*JNJ VEGA Study, Feagan, B. G. et al. Lancet Gastroenterol. Hepatol. 8, 307–320 (2023)
Remission rates
TNFα
IL-23
TNFα + IL-23
*JNJ VEGA Study, Feagan, B. G. et al. Lancet Gastroenterol. Hepatol. 8, 307–320 (2023)
Man with glasses sitting on couch looks to the right
Man with glasses sitting on couch looks to the right
Man with glasses sitting on couch looks to the right

PRECISION IMMUNOLOGY APPROACHES TO PATIENT SELECTION

We are working to develop genetic- or biomarker-based patient selection approaches across our portfolio of therapeutics to help identify patients who may have higher likelihood of benefiting from our investigational products, if approved.

We are pursuing patient selection approaches informed by recent findings from research* showing promise in IBD:

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Banner Pattern image
*Prometheus Biosciences APOLLO-UC Phase 2 Study, Sands, Bruce E., et al. Gastroenterology 164.6 (2023)