CORPORATE OVERVIEW

Spyre is focused on developing next generation therapeutics for people living with IBD, including ulcerative colitis (UC) and Crohn’s disease (CD).

Our portfolio of novel and proprietary monoclonal antibody product candidates has the potential to address unmet needs in IBD care and, if approved, we believe our pipeline candidates may provide promising treatment options to help patients living with IBD.

Man and woman wearing fall clothing walk golden retriever with mountains in background
Man and woman wearing fall clothing walk golden retriever with mountains in background
Man and woman wearing fall clothing walk golden retriever with mountains in background

DISEASE FOCUS / MARKET OPPORTUNITY

IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders: UC and CD.

IBD affects millions of individuals worldwide. In the United States, it is estimated that approximately 2.4 million individuals are currently diagnosed with IBD.

A range of pharmaceutical options to address IBD exists, including anti-inflammatory drugs, immunosuppressants, and biologics. Treatment plans are often tailored to the individual’s disease severity, location, and response to therapy. In some cases, surgical interventions such as bowel resection or ostomy formation may be necessary.

There remain substantial unmet needs in IBD management, including:

Adequacy and duration of response, with limited options for people with refractory or severe disease.

Side effects and safety concerns associated with long-term medication use.

Adherence to dosing regimens.

Logo of Paragon Therapeutics

Our portfolio of potentially best-in-class antibodies was discovered and developed by our partner, Paragon Therapeutics. Spyre is the second company that was founded upon technology spun out of Paragon, a group of leading entrepreneurial scientists and investors with extensive monoclonal antibody experience.